Table 4.
Medical status of ADNP positive and ADNP negative subjects
| Characteristica | ADNP+b | ADNP− | p-valued |
|---|---|---|---|
| BMI (kg/m2) at initial visit, mean (SD) | 25.3 (4.4) | 26.6 (5.0) | <0.0001 |
| BMI (kg/m2) at initial visit, categorized, n (%) | |||
| <18.5 | 39 (3.5%) | 6 (2.1%) | 0.0001 |
| 18.5 to 24.9 | 495 (43.7%) | 101 (35.0%) | |
| 25–29.9 | 431 (38.1%) | 115 (39.8%) | |
| 30 or higher | 167 (14.8%) | 67 (23.2%) | |
| BMI (kg/m2) at most recent visitc, mean (SD) | 24.9 (4.5) | 26.6 (5.5) | 0.0001 |
| BMI (kg/m2) at most recent visitc, categorized, n (%) | |||
| <18.5 | 34 (6.3%) | 8 (5.2%) | 0.002 |
| 18.5 to 24.9 | 222 (41.3%) | 47 (30.3%) | |
| 25–29.9 | 210 (39.0%) | 64 (41.3%) | |
| 30 or higher | 72 (13.4%) | 36 (23.2%) | |
| Systolic blood pressure at initial visit, mean (SD) | 132.5 (19.1) | 133.8 (21.2) | 0.31 |
| Diastolic blood pressure at initial visit, mean (SD) | 72.8 (10.5) | 72.9 (10.5) | 0.93 |
| Hypertension, n (%) | 642 (56.7%) | 184 (63.7%) | 0.03 |
| Diabetes, n (%) | 112 (9.9%) | 48 (16.6%) | 0.002 |
| Hypercholesterolemia, n (%) | 600 (53.2%) | 158 (54.9%) | 0.62 |
| Stroke, n (%) | 133 (11.8%) | 40 (13.8%) | 0.35 |
| Cardiovascular disease, n (%) | 352 (31.2%) | 111 (38.4%) | 0.02 |
| Thyroid disease, n (%) | 249 (22.0%) | 74 (25.7%) | 0.19 |
| Atrial fibrillation, n (%) | 160 (14.1%) | 47 (16.3%) | 0.35 |
| Smoking history, n (%) | 521 (46.0%) | 143 (49.5%) | 0.29 |
| Antihypertensive use at any visit, n (%) | 657 (58.0%) | 192 (66.4%) | 0.01 |
| Antilipid medication at any visit, n (%) | 523 (46.2%) | 134 (46.4%) | 0.96 |
Abbreviations: NC = normal cognition; MCI = mild cognitive impairment; AD = Alzheimer’s disease; UDS = Uniform Data Set; CDR-SB = Clinical Dementia Rating Sum of Boxes; APOE = apolipoprotein E
Number missing data: diabetes (ADNP+, n = 1; ADNP-, n = 0); hypercholesterolemia (ADNP+, n = 5; ADNP-, n=1); thyroid disease (ADNP+, n = 2; ADNP-, n =1); stroke (ADNP+, n = 7; ADNP-, n = 0); cardiovascular disease (ADNP+, n = 3; ADNP-, n =0); atrial fibrillation (ADNP+, n = 0; ADNP-, n = 1); systolic blood pressure (ADNP+, n = 27; ADNP-, n = 7); diastolic blood pressure (ADNP+, n = 27; ADNP-, n = 7)
Moderate to frequent neuritic plaques and Braak Stage III-VI
Among the 538 ADNP+ and 155 ADNP- subjects with longitudinal BMI measurements
Unadjusted logistic regression