Table 7.
Characteristics of mothers who started cART in the first trimester with boosted PI versus non-boosted PI
| Characteristic | PI not boosted (N=33) |
Boosted PI (N=97) |
P Value |
|
|---|---|---|---|---|
| Maternal age (yr) | Median (Q1, Q3) | 30.3 (24.0, 33.9) | 29.6 (25.7, 33.6) | 0.72 |
| Mother born on US mainland | 19 (58%) | 60 (62%) | 0.66 | |
| High school graduate | 18 (55%) | 66 (68%) | 0.16 | |
| Annual Income < 10K | 21 (64%) | 39 (40%) | 0.03 | |
| Pre-pregnancy BMI (kg/m2) | Median (Q1, Q3) | 27.5 (24.4, 36.2) | 26.6 (24.2, 32.9) | 0.53 |
| Single (not living with partner/spouse) | 20 (61%) | 55 (57%) | 0.69 | |
| Race/ethnicity Mom/caregiver | Black Non-Hispanic | 14 (42%) | 59 (61%) | 0.20 |
| Hispanic | 16 (48%) | 28 (29%) | ||
| White Non-Hispanic | 3 (9%) | 8 (8%) | ||
| Multiracial/other/unknown | 0 (0%) | 1 (1%) | ||
| English only spoken at home | English | |||
| Not currently working | 22 (67%) | 74 (76%) | 0.28 | |
| Illicit drugs - used in first trimester | 2 (6%) | 10 (10%) | 0.48 | |
| Alcohol drugs - used in first trimester | 1 (3%) | 14 (15%) | 0.08 | |
| Tobacco drugs - used in first trimester | 11 (34%) | 19 (20%) | 0.09 | |
| Clinical site by region | NY-NJ | 7 (21%) | 28 (29%) | 0.03 |
| West | 8 (24%) | 20 (21%) | ||
| Florida | 1 (3%) | 18 (19%) | ||
| South | 6 (18%) | 13 (13%) | ||
| Chicago | 4 (12%) | 13 (13%) | ||
| Puerto Rico | 7 (21%) | 5 (5%) | ||
| CD4 percent (%) before cART | Median (Q1, Q3) | 27 (24, 33) | 25 (16, 32) | 0.28 |
| Log10 HIV RNA before cART | Median (Q1, Q3) | 3.8 (3.3, 4.2) | 3.9 (3.2, 4.4) | 0.64 |
| CD4 percent (%) 3rd trimester | Median (Q1, Q3) | 32 (27, 36) | 26 (20, 38) | 0.15 |
| Log RNA 3rd trimester | Median (Q1, Q3) | 1.9 (1.7, 2.2) | 1.7 (1.7, 2.0) | 0.11 |
| Year of birth | 2005 | 3 (9%) | 1 (1%) | <0.001 |
| 2006 | 11 (33%) | 2 (2%) | ||
| 2007 | 9 (27%) | 13 (13%) | ||
| 2008 | 4 (12%) | 28 (29%) | ||
| 2009 | 2 (6%) | 24 (25%) | ||
| 2010 | 4 (12%) | 26 (27%) | ||
| 2011 | 0 (0%) | 3 (3%) | ||
| Use of ARV before this pregnancy | Yes | 9 (27%) | 43 (44%) | 0.07 |
| No | 5 (15%) | 20 (21%) | ||
| Unknown | 19 (58%) | 34 (35%) |
Abbreviations: ARV=antiretroviral therapy, BMI=body mass index, FTC=emtricitabine, TFV=tenofovir, ZDV=zidovudine, 3TC=lamivudine, cART= combination antiretroviral therapy, Q1=25th percentile, Q3=75th percentile