Table 8.
Characteristics of mothers who started cART in the second trimester with boosted PI versus non-boosted PI
| Characteristic | PI not boosted (N=74) |
Boosted PI (N=239) |
P Value |
|
|---|---|---|---|---|
| Maternal age (yr) | Median (Q1, Q3) | 27.9 (23.4, 33.4) | 27.1 (23.1, 32.1) | 0.61 |
| Mother born on US mainland | 33 (45%) | 167 (71%) | <0.001 | |
| High school graduate | 45 (61%) | 161 (69%) | 0.22 | |
| Annual Income <10K | <10K | 37 (50%) | 97 (41%) | 0.17 |
| Pre-pregnancy BMI (kg/m2) | Median (Q1, Q3) | 30.6 (25.4, 35.8) | 26.8 (23.3, 36.7) | 0.27 |
| Single (not living with partner/spouse) | 31 (42%) | 138 (58%) | 0.014 | |
| Race/ethnicity Mom/caregiver | Black Non-Hispanic | 27 (38%) | 142 (61%) | <0.001 |
| Hispanic | 42 (58%) | 63 (27%) | ||
| White Non-Hispanic | 3 (4%) | 20 (9%) | ||
| Multirace/other/unknown | 0 (0%) | 8 (3%) | ||
| English only spoken at home | 43 (58%) | 70 (30%) | <0.001 | |
| Not currently working | 47 (64%) | 167 (70%) | 0.26 | |
| Illicit drugs - used in first trimester | 7 (10%) | 11 (5%) | 0.11 | |
| Alcohol - used in first trimester | 5 (7%) | 15 (7%) | 0.86 | |
| Tobacco - used in first trimester | 13 (19%) | 38 (17%) | 0.70 | |
| Clinical site by region | NY-NJ | 18 (24%) | 60 (25%) | <0.001 |
| South | 8 (11%) | 69 (29%) | ||
| Puerto Rico | 28 (38%) | 24 (10%) | ||
| Chicago | 6 (8%) | 30 (13%) | ||
| West | 9 (12%) | 27 (11%) | ||
| Florida | 4 (5%) | 27 (11%) | ||
| Mid-Atlantic | 1 (1%) | 2 (1%) | ||
| CD4 percent before cART | Q1, Q3 | 29 (22, 35) | 24 (18, 33) | 0.03 |
| Log10 RNA before cART | Median (Q1, Q3) | 3.6 (3.1, 4.2) | 3.8 (3.2, 4.4) | 0.34 |
| CD4 3rd trimester | Median (Q1, Q3) | 33 (28, 38) | 29 (23, 38) | 0.07 |
| Log10 HIV RNA 3rd trimester | Median (Q1, Q3) | 1.9 (1.7, 2.6) | 1.9 (1.7, 2.3) | 0.03 |
| Year of birth | 2005 | 11 (15%) | 7 (3%) | <0.001 |
| 2006 | 18 (24%) | 19 (8%) | ||
| 2007 | 21 (28%) | 35 (15%) | ||
| 2008 | 7 (9%) | 62 (26%) | ||
| 2009 | 8 (11%) | 53 (22%) | ||
| 2010 | 6 (8%) | 56 (23%) | ||
| 2011 | 3 (4%) | 7 (3%) | ||
| Use of ARV before this pregnancy | Yes | 12 (16%) | 67 (28%) | 0.12 |
| No | 22 (30%) | 61 (26%) | ||
| Unknown | 40 (54%) | 111 (46%) |
Abbreviations: ARV=antiretroviral therapy, BMI=body mass index, FTC=emtricitabine, TFV=tenofovir, ZDV=zidovudine, 3TC=lamivudine, cART= combination antiretroviral therapy, PI= protease inhibitor, Q1=25th percentile, Q3=75th percentile