Table 7.
Incidence of Cardiac Lesions at PND90
| AGE | Exposure Duration | Sex/Pathology | 0 | BPA 2.5 | BPA 25 | BPA 2500 | BPA 25000 | EE2 0.05 | EE2 0.5 |
|---|---|---|---|---|---|---|---|---|---|
| PND 90 | Stop | Male | |||||||
| Cardiomyopathy | 10/10 (1.9) | 10/10 (1.5) | 8/8 (1.5) | 9/10 (1.3) | 9/9 (2.0) | 10/10 (1.6) | 9/10 (1.4) | 10/10 (1.6) | |
| Focal Fibrosis | 2/10 | 3/10 | 4/8 | 2/10 | 5/9 | 3/10 | 4/10 | 3/10 | |
| Inflammation/Necrosis | 4/10 | 1/10 | 3/8 | 2/10 | 3/9 | 3/10 | 2/10 | 2/10 | |
| Diffuse Degeration | --- | --- | --- | 2/10 | 1/10 | 2/10 | 1/10 | ||
| Stop | Female | ||||||||
| Cardiomyopathy | 10/10 (1.4) | 8/8 (1.4) | 10/10 (1.1) | 10/10 (1.1) | 7/8 (0.9) | 10/10 (1.5) | 10/10 (1.3) | 10/10 (2.0) | |
| Focal Fibrosis | 4/10 | 2/8 | 6/10 | 3/10 | 6/8 | 5/10 | 5/10 | 7/10 | |
| Inflammation/Necrosis | 1/10 | 3/8 | 2/10 | 2/10 | 1/10 | 1/10 | 0/10 | 1/10 | |
| Diffuse Degeration | --- | --- | --- | 1/10 | --- | --- | --- | --- | |
| Continuous | Male | ||||||||
| Cardiomyopathy | 10/10 (1.3) | 9/9 (1.8) | 8/8 (1.9) | 10/10 (1.9) | 8/8 (1.6) | 9/10 (1.6) | 10/10 (1.5) | 10/10 (1.7) | |
| Focal Fibrosis | 5/10 | 2/9 | 4/8 | 4/10 | 2/8 | 3/10 | 1/10 | 4/10 | |
| Inflammation/Necrosis | 4/10 | 3/9 | 4/8 | 6/10 | 3/8 | 4/10 | 3/10 | 3/10 | |
| Diffuse Degeration | --- | --- | 1/8 | 2/10 | --- | 1/10 | --- | 2/10 | |
| Continuous | Female | ||||||||
| Cardiomyopathy | 10/10 (1.5) | 9/10 (1.6) | 9/10 (1.2) | 10/10 (1.7) | 9/9 (1.4) | 10/10 (1.3) | 10/10 (1.4) | 10/10 (1.3) | |
| Focal Fibrosis | 1/10 | 6/10 | 2/10 | 6/10 | 3/9 | 3/10 | 4/10 | 6/10 | |
| Inflammation/Necrosis | 1/10 | 1/10 | 2/10 | 0/10 | 0/10 | 2/10 | 2/10 | 2/10 | |
| Diffuse Degeration | --- | 1/10 | 1/10 | --- | --- | --- | 1/10 | --- | |
Shown in parantheses are the mean severity score for cardiomyopathy.