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. Author manuscript; available in PMC: 2018 Mar 9.
Published in final edited form as: Cell. 2017 Mar 9;168(6):1041–1052.e18. doi: 10.1016/j.cell.2017.02.011

Figure 2. Partial c-Kit activation induced by SCF variants with crippled dimerization interface.

Figure 2

(A–C) Induction kinetics of (A) ERK1/2 phosphorylation, (B) AKT phosphorylation and (C) c-Kit internalization after stimulation with 1 μM of indicated SCF variants. (D and E) Dose response of (D) ERK1/2 phosphorylation and (E) AKT phosphorylation at 5 min of stimulation with indicated SCF variants. (A–E) Experiments were performed using mouse MC/9 mast cells. Data represent the mean ± SEM in triplicates and are representative of at least two independent replicates. MFI = mean fluorescence intensity; a.u. = arbitrary units.