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. Author manuscript; available in PMC: 2018 Mar 9.
Published in final edited form as: Cell. 2017 Mar 9;168(6):1041–1052.e18. doi: 10.1016/j.cell.2017.02.011

Figure 3. “Biased” signaling activation induced by S4-3a.

Figure 3

(A) Bubble plot representation of the signaling pathways activated by SCF and S4-3a at the indicated times in MC/9 mast cells. The size of the bubble represents the intensity of the signaling activated. (B) The levels of signal activation induced by S4-3a at 5 min of stimulation were normalized to those induced by SCF and order based on signaling potency. The red line represents the SCF signaling potency normalized to 100%. (C) pAKT, pERK and pp38 kinetics experiments performed in MC/9 cells stimulated with SCF (top) or S4-3a (bottom). (A–C) Stimulation was performed with 1 μM SCF or S4-3a. Data represent mean ± SD and are from three independent experiments. See also Table S1.