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. 2017 Jul 13;11(7):e0005680. doi: 10.1371/journal.pntd.0005680

Fig 6. A smpde4A transgene restores wild type motility rates to pde4-deficient C. elegans.

Fig 6

Relative to wild type (WT) C. elegans, a loss of function allele of pde4, namely ce268 [103], causes hypermotility. This hypermotility is reverted back to WT rates upon transgenic expression of a full-length cDNA for smpde4a. Results for two independently generated lines, smpde4a(a) and smpde4a(b) are shown. The same transgenes do not alter the motility of otherwise WT animals. Error bars indicate the standard deviations around the mean motility in a representative experiment with at least 10 worms for each strain. The asterisks indicate significance by Student’s t-test (*p<0.005; **p<0.0005) relative to the hypermotility recorded for the pde4(ce268) mutant.