Table 3.

Diagnostic Performance of the Three Screening Modalities Used Alone and in Combination

Screening Modality	Sensitivity*	P†	Specificity‡	P†	PPV	P†	NPV	P†
US
No./total No.	15/40	< .001	1,284/1,325	< .001	15/56	.145	1,284/1,309	< .001
Rate, %	37.5		96.9		26.8		98.1
95% CI	24.2 to 53.0		95.8 to 97.7		1.70 to 3.96		97.2 to 98.7
MG
No./total No.	15/40	< .001	1,287/1,325	< .001	15/53	.105	1,287/1,312	< .001
Rate, %	37.5		97.1		28.3		98.1
95% CI	24.2 to 53.0		96.1 to 97.9		18.0 to 41.6		97.2 to 98.7
MRI
No./total No.	36/40	NA	1,178/1,325	NA	36/183	NA	1,178/1,182	NA
Rate, %	90.0		88.9		19.7		99.7
95% CI	76.9 to 96.0		87.1 to 90.5		14.6 to 26.0		99.1 to 99.9
US + MG
No./total No.	20/40	< .001	1,268/1,325	< .001	20/77	.111	1,268/1,288
Rate, %	50.0		95.7		26.0		98.4	< .001
95% CI	35.2 to 64.8		94.5 to 96.7		17.5 to 36.7		97.6 to 99.0
US + MRI
No./total No.	36/40	1.000	1,163/1,325	< .001	36/198	< .001	1,163/1,167	.075
Rate, %	90.0		87.8		18.2		99.7
95% CI	76.9 to 96.0		85.9 to 89.4		13.4 to 24.1		99.1 to 99.9
MG + MRI
No./total No.	38/40	.148	1,168/1,325	< .001	38/195	.788	1,168/1,170	.161
Rate, %	95.0		88.2		19.5		99.8
95% CI	83.5 to 98.6		86.3 to 89.8		14.5 to 25.6		99.4 to 100.0
US + MG + MRI
No./total No.	38/40	.148	1,159/1,325	< .001	38/204	.168	1,159/1,161	.165
Rate, %	95.0		87.5		18.6		99.8
95% CI	83.5 to 98.6		85.6 to 89.1		13.9 to 24.5		99.4 to 100.0

Abbreviations: MG, mammography; MRI, magnetic resonance imaging; NA, not applicable; NPV, negative predictive value; PPV, positive predictive value; US, ultrasound.

^*Cancers detected.

^†P values were calculated using the generalized estimating equation model and are presented for comparison of the diagnostic performance of each modality or combination of modalities with the diagnostic performance of MRI alone.

^‡Cancer correctly not detected.