Table 3.
Screening Modality | Sensitivity* | P† | Specificity‡ | P† | PPV | P† | NPV | P† |
---|---|---|---|---|---|---|---|---|
US | ||||||||
No./total No. | 15/40 | < .001 | 1,284/1,325 | < .001 | 15/56 | .145 | 1,284/1,309 | < .001 |
Rate, % | 37.5 | 96.9 | 26.8 | 98.1 | ||||
95% CI | 24.2 to 53.0 | 95.8 to 97.7 | 1.70 to 3.96 | 97.2 to 98.7 | ||||
MG | ||||||||
No./total No. | 15/40 | < .001 | 1,287/1,325 | < .001 | 15/53 | .105 | 1,287/1,312 | < .001 |
Rate, % | 37.5 | 97.1 | 28.3 | 98.1 | ||||
95% CI | 24.2 to 53.0 | 96.1 to 97.9 | 18.0 to 41.6 | 97.2 to 98.7 | ||||
MRI | ||||||||
No./total No. | 36/40 | NA | 1,178/1,325 | NA | 36/183 | NA | 1,178/1,182 | NA |
Rate, % | 90.0 | 88.9 | 19.7 | 99.7 | ||||
95% CI | 76.9 to 96.0 | 87.1 to 90.5 | 14.6 to 26.0 | 99.1 to 99.9 | ||||
US + MG | ||||||||
No./total No. | 20/40 | < .001 | 1,268/1,325 | < .001 | 20/77 | .111 | 1,268/1,288 | |
Rate, % | 50.0 | 95.7 | 26.0 | 98.4 | < .001 | |||
95% CI | 35.2 to 64.8 | 94.5 to 96.7 | 17.5 to 36.7 | 97.6 to 99.0 | ||||
US + MRI | ||||||||
No./total No. | 36/40 | 1.000 | 1,163/1,325 | < .001 | 36/198 | < .001 | 1,163/1,167 | .075 |
Rate, % | 90.0 | 87.8 | 18.2 | 99.7 | ||||
95% CI | 76.9 to 96.0 | 85.9 to 89.4 | 13.4 to 24.1 | 99.1 to 99.9 | ||||
MG + MRI | ||||||||
No./total No. | 38/40 | .148 | 1,168/1,325 | < .001 | 38/195 | .788 | 1,168/1,170 | .161 |
Rate, % | 95.0 | 88.2 | 19.5 | 99.8 | ||||
95% CI | 83.5 to 98.6 | 86.3 to 89.8 | 14.5 to 25.6 | 99.4 to 100.0 | ||||
US + MG + MRI | ||||||||
No./total No. | 38/40 | .148 | 1,159/1,325 | < .001 | 38/204 | .168 | 1,159/1,161 | .165 |
Rate, % | 95.0 | 87.5 | 18.6 | 99.8 | ||||
95% CI | 83.5 to 98.6 | 85.6 to 89.1 | 13.9 to 24.5 | 99.4 to 100.0 |
Abbreviations: MG, mammography; MRI, magnetic resonance imaging; NA, not applicable; NPV, negative predictive value; PPV, positive predictive value; US, ultrasound.
Cancers detected.
P values were calculated using the generalized estimating equation model and are presented for comparison of the diagnostic performance of each modality or combination of modalities with the diagnostic performance of MRI alone.
Cancer correctly not detected.