Table 5.
Diagnostic Performance of Ultrasound, Mammography, and MRI, Depending on the Number of Screening Round, Mutation Status, Age, and Breast Density
| Screening Modality | Screening Round |
Mutation Status |
Age |
ACR Breast Composition |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First | Subsequent | P | Wild Type | BRCA | P | ≤ 50 Years | > 50 Years | P | Grade 1/2 | Grade 3/4 | P | |
| Ultrasound | ||||||||||||
| Sensitivity | ||||||||||||
| Rate | 47.4 | 28.6 | .234 | 29.4 | 37.5 | .783 | 26.9 | 57.1 | .089 | 38.5 | 35.7 | 1.000 |
| No./total No. | 9/19 | 6/21 | 5/17 | 6/16 | 7/26 | 8/14 | 10/26 | 5/14 | ||||
| Specificity | ||||||||||||
| Rate | 95.7 | 97.7 | .038* | 96.1 | 99.1 | .022* | 95.9 | 99.2 | .005* | 97.6 | 96.1 | .114 |
| No./total No. | 517/540 | 767/785 | 660/687 | 449/453 | 898/936 | 386/389 | 662/678 | 622/647 | ||||
| PPV | ||||||||||||
| Rate | 28.1 | 25.0 | 1.000 | 15.6 | 60.0 | .011* | 15.6 | 72.7 | .000* | 38.5 | 16.7 | .079 |
| No./total No. | 9/32 | 6/24 | 5/32 | 6/10 | 7/45 | 8/11 | 10/26 | 5/30 | ||||
| NPV | ||||||||||||
| Rate | 98.1 | 98.1 | .978 | 98.2 | 97.8 | .661 | 97.9 | 98.5 | .520 | 97.6 | 98.6 | .258 |
| No./total No. | 517/527 | 767/782 | 660/672 | 449/459 | 898/917 | 386/392 | 662/678 | 622/631 | ||||
| Mammography | ||||||||||||
| Sensitivity | ||||||||||||
| Rate | 42.1 | 33.3 | .592 | 29.4 | 43.8 | .798 | 34.6 | 42.9 | .736 | 34.6 | 42.9 | .736 |
| No./total No. | 8/19 | 7/21 | 5/17 | 7/16 | 9/26 | 6/14 | 9/26 | 6/14 | ||||
| Specificity | ||||||||||||
| Rate | 96.5 | 97.6 | .272 | 96.4 | 98.9 | .013* | 96.8 | 97.9 | .336 | 98.2 | 96.0 | .024* |
| No./total No. | 521/540 | 766/785 | 662/687 | 448/453 | 906/936 | 381/389 | 666/678 | 621/647 | ||||
| PPV | ||||||||||||
| Rate | 29.6 | 26.9 | 1.000 | 16.7 | 58.3 | .019* | 23.1 | 42.9 | .182 | 42.9 | 18.8 | .070 |
| No./total No. | 8/27 | 7/26 | 5/30 | 7/12 | 9/39 | 6/14 | 9/21 | 6/32 | ||||
| NPV | ||||||||||||
| Rate | 97.9 | 98.2 | .729 | 98.2 | 98.0 | .824 | 98.2 | 97.9 | .796 | 97.5 | 98.7 | .116 |
| No./total No. | 521/532 | 766/780 | 662/674 | 448/457 | 906/923 | 381/389 | 666/683 | 621/629 | ||||
| MRI | ||||||||||||
| Sensitivity | ||||||||||||
| Rate | 89.5 | 90.5 | .916 | 94.1 | 81.3 | .191 | 92.3 | 85.7 | .602 | 92.3 | 85.7 | .602 |
| No./total No. | 17/19 | 19/21 | 16/17 | 13/16 | 24/26 | 12/14 | 24/26 | 12/14 | ||||
| Specificity | ||||||||||||
| Rate | 84.6 | 91.8 | < .001* | 86.6 | 94.3 | < .001* | 87.9 | 91.3 | .091 | 90.6 | 87.2 | .065 |
| No./total No. | 457/540 | 721/785 | 595/687 | 427/453 | 823/936 | 355/389 | 614/678 | 564/647 | ||||
| PPV | ||||||||||||
| Rate | 17.0 | 22.9 | .354 | 14.8 | 33.3 | .018* | 17.5 | 26.1 | .283 | 27.3 | 12.6 | .016* |
| No./total No. | 17/100 | 19/83 | 16/108 | 13/39 | 24/137 | 12/46 | 24/88 | 12/95 | ||||
| NPV | ||||||||||||
| Rate | 99.6 | 99.7 | .649 | 99.8 | 99.3 | .217 | 99.8 | 99.4 | .402 | 99.7 | 99.6 | .932 |
| No./total No. | 457/459 | 721/723 | 595/596 | 427/430 | 823/825 | 355/357 | 614/616 | 564/566 | ||||
Abbreviations: ACR, American College of Radiology; MRI, magnetic resonance imaging; NPV, negative predictive value; PPV, positive predictive value.
*
Significant differences = P < .05; P values are presented for the comparison of subgroups for each modality separately. (P values for the comparison of different modalities within a subgroup are described in the text.)