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. 2015 Feb 23;33(10):1128–1135. doi: 10.1200/JCO.2014.56.8626

Table 5.

Diagnostic Performance of Ultrasound, Mammography, and MRI, Depending on the Number of Screening Round, Mutation Status, Age, and Breast Density

Screening Modality Screening Round
Mutation Status
Age
ACR Breast Composition
First Subsequent P Wild Type BRCA P ≤ 50 Years > 50 Years P Grade 1/2 Grade 3/4 P
Ultrasound
    Sensitivity
        Rate 47.4 28.6 .234 29.4 37.5 .783 26.9 57.1 .089 38.5 35.7 1.000
        No./total No. 9/19 6/21 5/17 6/16 7/26 8/14 10/26 5/14
    Specificity
        Rate 95.7 97.7 .038* 96.1 99.1 .022* 95.9 99.2 .005* 97.6 96.1 .114
        No./total No. 517/540 767/785 660/687 449/453 898/936 386/389 662/678 622/647
    PPV
        Rate 28.1 25.0 1.000 15.6 60.0 .011* 15.6 72.7 .000* 38.5 16.7 .079
        No./total No. 9/32 6/24 5/32 6/10 7/45 8/11 10/26 5/30
    NPV
        Rate 98.1 98.1 .978 98.2 97.8 .661 97.9 98.5 .520 97.6 98.6 .258
        No./total No. 517/527 767/782 660/672 449/459 898/917 386/392 662/678 622/631
Mammography
    Sensitivity
        Rate 42.1 33.3 .592 29.4 43.8 .798 34.6 42.9 .736 34.6 42.9 .736
        No./total No. 8/19 7/21 5/17 7/16 9/26 6/14 9/26 6/14
    Specificity
        Rate 96.5 97.6 .272 96.4 98.9 .013* 96.8 97.9 .336 98.2 96.0 .024*
        No./total No. 521/540 766/785 662/687 448/453 906/936 381/389 666/678 621/647
    PPV
        Rate 29.6 26.9 1.000 16.7 58.3 .019* 23.1 42.9 .182 42.9 18.8 .070
        No./total No. 8/27 7/26 5/30 7/12 9/39 6/14 9/21 6/32
    NPV
        Rate 97.9 98.2 .729 98.2 98.0 .824 98.2 97.9 .796 97.5 98.7 .116
        No./total No. 521/532 766/780 662/674 448/457 906/923 381/389 666/683 621/629
MRI
    Sensitivity
        Rate 89.5 90.5 .916 94.1 81.3 .191 92.3 85.7 .602 92.3 85.7 .602
        No./total No. 17/19 19/21 16/17 13/16 24/26 12/14 24/26 12/14
    Specificity
        Rate 84.6 91.8 < .001* 86.6 94.3 < .001* 87.9 91.3 .091 90.6 87.2 .065
        No./total No. 457/540 721/785 595/687 427/453 823/936 355/389 614/678 564/647
    PPV
        Rate 17.0 22.9 .354 14.8 33.3 .018* 17.5 26.1 .283 27.3 12.6 .016*
        No./total No. 17/100 19/83 16/108 13/39 24/137 12/46 24/88 12/95
    NPV
        Rate 99.6 99.7 .649 99.8 99.3 .217 99.8 99.4 .402 99.7 99.6 .932
        No./total No. 457/459 721/723 595/596 427/430 823/825 355/357 614/616 564/566

Abbreviations: ACR, American College of Radiology; MRI, magnetic resonance imaging; NPV, negative predictive value; PPV, positive predictive value.

*

Significant differences = P < .05; P values are presented for the comparison of subgroups for each modality separately. (P values for the comparison of different modalities within a subgroup are described in the text.)