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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Proc IEEE Inst Electr Electron Eng. 2016 Sep 28;105(1):139–157. doi: 10.1109/JPROC.2016.2577380

Fig. 5.

Fig. 5

Calcium transient detection. (A) Two photon imaging of calcium signals in cerebellar Purkinje cell dendrites. (B) Simultaneous calcium imaging and electrophysiology (with pipette shown in panel A) to record ”ground truth” data. A, B from [158] with permission. (C) Generation of surrogate data. (D) Performance approaches the Cramer-Rao bound with increasing SNR. GCaMP6s provides better detectability than OGB-1 or GCaMP6f. (E) Validation with experimental GCaMP6s data. (F) Receiver Operating Characteristic (ROC) analysis of perfomance on real data, comparing the deconvolution approach of Vogelstein et al. [161] with our original [158] and updated [160] algorithms.