Table 3.

Differential gene–smoking interaction in CD and UC

Smoking contrast	Chr	SNP	Minor allele	CD			UC			p*
				OR [95% CI]	p	ph	OR [95% CI]	p	ph
never vs ever	6	rs3127599	A	1.10 [1.04, 1.17]	1.5×10−3	0.88	0.91 [0.85, 0.97]	7.1×10−3	0.19	3.6×10−5
	11	rs117833518	A	0.81 [0.70, 0.95]	8.4×10−3	0.49	1.33 [1.12, 1.58]	1.2×10−3	0.86	3.0×10−5
	19	rs2230330	A	0.58 [0.38, 0.87]	8.7×10−3	0.76	1.84 [1.18, 2.85]	6.8×10−3	0.63	1.6×10−4
never vs current	6	rs176095	G	1.12 [1.04, 1.21]	3.3×10−3	0.33	0.83 [0.74, 0.94]	4.3×10−3	0.94	7.1×10−5
	14	rs10400765	G	0.90 [0.83, 0.97]	7.3×10−3	0.75	1.19 [1.06, 1.34]	3.4×10−3	0.41	8.6×10−5
	16	rs9940076	A	1.09 [1.02, 1.17]	7.3×10−3	0.92	0.85 [0.77, 0.94]	1.6×10−3	0.58	4.1×10−5
never vs former	1	rs6682359	A	1.12 [1.03, 1.22]	5.8×10−3	0.94	0.91 [0.85, 0.98]	9.0×10−3	0.56	1.5×10−4

Chr: chromosome; OR, p: genotypic odds ratio for exposure (see Methods) and p value from a fixed-effects inverse-variance meta-analysis, based upon center -specific Wald tests. Before meta-analysis, p values were individually adjusted for possible population stratification, following a genomic control approach. p_h: heterogeneity (across study center) p value from a Cochrane Q test; p*: p value from a heterogeneity (Cochrane Q) test of OR differences in the CD and UC; 95% CI: 95% confidence interval.