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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Gastroenterology. 2017 Apr 21;153(2):521–535.e20. doi: 10.1053/j.gastro.2017.04.020

Figure 3.

Figure 3

ICC expansion occurs despite reduced Kitl expression in Leprdb/db mice. (A) Reduced expression of mRNA encoding the 248-amino-acid, “soluble” KITL isoform subject to rapid cleavage (sKitl) and mRNA common to both sKITL and the 220-amino-acid “membrane-bound” isoform (total KITL; tKitl) in the gastric corpus+antrum tunica muscularis of Leprdb/db mice vs. WT mice (n=11–13/group). (B) Reduced expression of 31-kDa KITL protein (corresponding to uncleaved, cell-associated KITL220 and secreted KITL produced from the KITL248 isoform16) in Leprdb/db mice (n=20/group).