Table 4.
Levels of injury and repair biomarkers by time point
| Urinary Biomarker | Day 0: Premarathon | Da 1: Immediately Postmarathon | Day 2: Postmarathon | Overall Pa |
|---|---|---|---|---|
| Injury Biomarkers | ||||
| KIM-1 (pg/ml) | 132.59* (67.61, 219.98) | 723.32 (459.36, 1970.64) | 702.42 (123.27, 1098.67) | <0.001 |
| TNF-α (pg/ml) | 0.02 (0.01, 0.04) | 0.09* (0.04, 0.18) | 0.02 (0.00, 0.04) | 0.001 |
| IL-18 (pg/ml) | 6.43 (4.24, 12.26) | 45.89* (23.42, 63.45) | 16.95 (4.84, 29.98) | <0.001 |
| IL-6 (pg/ml) | 0.05 (0.03, 0.15) | 0.96* (0.38, 2.24) | 0.19 (0.08, 0.30) | <0.001 |
| IL-8 (pg/ml) | 4.80 (0.92, 20.65) | 43.87* (9.93, 123.00) | 9.31 (2.88, 23.11) | 0.01 |
| NGAL (ng/ml) | 8.00 (4.15, 30.48) | 37.64* (19.03, 84.61) | 18.49 (9.25, 33.69) | 0.001 |
| Repair Biomarkers | ||||
| YKL-40 (pg/ml) | 96.25 (43.96, 124.31) | 865.13* (466.84, 1764.28) | 202.97 (55.91, 398.81) | <0.001 |
| MCP-1 (pg/ml) | 39.56 (26.12, 79.29) | 264.47* (131.12, 702.01) | 186.28(55.91, 366.74) | <0.001 |
Note: Unless otherwise indicated, values are given as median [interquartile range].
IL, interleukin; KIM-1, kidney injury molecule 1; MCP-1, monocyte chemoattractant protein-1; NGAL, neutrophil gelatinase-associated lipocalin; TNF-α, tumor necrosis factor α; YKL-40, human cartilage glycoprotein 39.
a
Overall p-values were obtained via Kruskal-Wallis Test.
*
Value is significantly different compared to the other two time points