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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Hum Mutat. 2017 Mar 15;38(9):1251–1258. doi: 10.1002/humu.23185

Fig. 3. Comparison of ROC and PRC curves for predicting MPRA expression in K562 cells.

Fig. 3

A) ROC and B) PRC for predicting MPRA expression in K562 cells (Kwasnieski et al., 2014) using different methods. All tested regions were within Segway/ChromHMM enhancer predictions in K562, but only ~20% were positive. DHS in the tested regions is also weak predictor of expression (green). However a gkm-SVM trained on DHS regions or Segway/ChromHMM regions is reasonably accurate (red and orange). The most accurate predictor is a gkm-SVM trained on DHS regions flanked by H3K27Ac and H3K4me1 (dark red).