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. 2017 Jul 26;9:238. doi: 10.3389/fnagi.2017.00238

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Copyright © 2017 Xiong, Lu, Zhu, Zeng, Shi, Jing, Xiang, Li, Tsang, Ruan and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Magnetic resonance imaging (MRI; 3D ASL) analysis showing changes in cerebral blood flow (CBF) in the vehicle and NBP-treated rat brains at different time points following bilateral common carotid artery occlusion (BCCAO). (A) CBF of the PC and hippocampus in the vehicle group is shown in the top row and the NBP-treated group in the second row. Likewise, CBF in the striatum with vehicle treatment is displayed in the third row, and the NBP-treated group is shown in the fourth row of images. The red color labeling represents increased CBF level, while green indicates lower CBF level. CBF quantitative analysis results in the cortex (B) hippocampus (C) and striatum (D) in the vehicle and BNP-treated groups at different time points after BCCAO. **p < 0.01; *p < 0.05. CT, cortex; Hip, hippocampus; Pre, pre-occlusion; BCCAO, bilateral common carotid artery occlusion; L, left; R, right.