Fig. 5.

BST-2 restricts bunyavirus replication in a host specific manner by modulating the incorporation of envelope glycoprotein into virions. SBV (A) and OROV (B) stocks were produced in the indicated BST2-expressing cells and virions pelleted by centrifugation followed by quantitative western blot analysis. The graph displays the average of the Gc/N ratio. The data of the Gc/N ratio of SBV in 293-hBST2 of Fig. 4B has been included here for comparative purposes. Data was analyzed using a 1-way repeated measures ANOVA followed by Dunnett's multiple comparison test. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001.