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. 2017 Jul 25;7:6390. doi: 10.1038/s41598-017-06231-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome profiles. (a) Gene distribution according to fold change, adjusted p-values, and direction of change (UP or DOWN). Orange shades are regions of significance (adjusted p-value < 0.05). TRAP genes are genes in the first quartile (Q1) of the TRAP list. Bins of 250 genes were used to calculate the median of fold change and p-value, and to count the number of TRAP genes in each bin. (b) Heatmaps, Venn diagrams and Pearson correlations of differentially expressed genes. Top, gene clustering according to log₂FC by Euclidean distance in the initial transcriptome (ALL genes) and in the list of genes filtered by Q1-TRAP list of adult astrocyte genes. Bottom, Venn diagrams of differentially expressed genes and Pearson correlations. There are major transcriptome changes upon VP16-CREB over-expression as compared to stimulation with FSK or NE, and the latter groups are highly similar. The same patterns are observed in ALL and TRAP genes. (c) PSCAN analysis of CRE-enrichment probability in ‘all’ and Q1-TRAP-filtered genes using promoters of mouse and human orthologs. The probability of CRE occurrence is highlighted in a spectrum of reds. Gray shades are transcriptome regions not analyzed. Rows are different matrices containing variations of CRE motifs. CRE-containing genes are enriched in the UP portion in all lists. (d) PSCAN analysis comparing ‘all’, ‘Q1-TRAP’ and ‘rest’, or remaining genes. CRE-containing genes are enriched in Q1-TRAP genes as compared to ‘rest’ genes.