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. 2017 Jul 25;7:6457. doi: 10.1038/s41598-017-06451-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ORAI1 and STIM1 protein abundance in neurons generated from healthy volunteers and from ChAc patients without or with lithium treatment without and with SGK1 inhibitor GSK650394. (a) Original Western blot of ORAI1 protein abundance in neurons differentiated from healthy volunteers (healthy) and in neurons from ChAc patients (ChAc). (b) Arithmetic means (±SEM, n = 4) of ORAI1 protein levels in neurons generated from healthy volunteers (white bar) and in neurons from ChAc patients (black bar). (c) Original Western blot of ORAI1 protein abundance in neurons from ChAc patients without (Ø) and with prior lithium (24 h, 2 mM) treatment without (+Li) and with (+Li + GSK) additional presence of SGK1 inhibitor GSK650394 (10 µM). (d) Arithmetic means (±SEM, n = 4) of ORAI1 protein levels in neurons differentiated from ChAc patients without (black bar) or with lithium (24 h, 2 mM) treatment without (light grey bar) and with (dark grey bar) presence of SGK1 inhibitor GSK650394 (10 µM). (e) Original Western blot of STIM1 protein abundance in neurons from ChAc patients without (Ø) and with prior lithium (24 h, 2 mM) treatment without (+Li) and with (+Li + GSK) additional presence of SGK1 inhibitor GSK650394 (10 µM). (f) Arithmetic means (±SEM, n = 3) of STIM1 protein abundance in neurons differentiated from ChAc patients without (black bar) or with lithium (24 h, 2 mM) treatment without (light grey bar) and with (dark grey bar) presence of SGK1 inhibitor GSK650394 (10 µM). ***(p < 0.001) indicates statistically significant difference to respective value in neurons from healthy volunteers, ^#(p < 0.05), ^##(p < 0.01) indicates statistically significant difference to respective value in absence of lithium. ^§(p < 0.05), ^§§(p < 0.01) indicates statistically significant difference to respective value in the absence of GSK650394.