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. 2017 Jul 25;7:6349. doi: 10.1038/s41598-017-06484-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The resistive index of intrarenal cortical artery is decreased in TLR4 deficiency mice to Ang-II. (A) Representative images of left kidney in short axis. The transducer is fixed to obtain a window showing cortical vessels. The pulse wave cursor is then centered on a cortical artery with its axis in parallel and vascular signals are obtained. Resistive index is calculated by the formula (PSV-EDV)/PSV. PSV, peak systolic velocity; EDV, end diastolic velocity. (B) Bar graph shows mean resistive index ± SEM. n = 6/group tested by ANOVA and Student’s t-test. *p < 0.05 vs. C3HeJ + saline, ^†p < 0.05 vs. C3HeOuJ + Ang-II, ^‡p < 0.05 vs. C3HeOuJ + saline. C3HeOuJ: normal TLR4, C3HeJ: TLR4 deficiency.