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. 2017 Jul 25;7:6374. doi: 10.1038/s41598-017-06696-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Whole-body conscious bioluminescence imaging of HIE and sham mice pre- and post-surgery. VSV-G pseudotyped NFκB biosensor was administered at birth to neonatal mice via intracranial injections (n = 22). Conscious whole-body bioluminescence imaging was conducted pre and post-surgery. The mice were split into two groups, HIE mice (n = 13) and sham control mice (n = 9). At P7 of development the HIE mice received surgery and both sets of mice were imaged daily until P19. There was a significant difference in fold change of luciferase expression between the HIE and sham mice over development (mean +/− SD, P < 0.0001). The fold change was specifically seen to be significantly higher (mean +/− SD, P < 0.001) between P14 and P16.