Figure 5.

Comparison of contrast sensitivity between V1 neurons in WT and Tg1 mice. (a) Left panel, cumulative histograms of C₅₀ for V1 neurons in WT and Tg1 mice. Right panel, The C₅₀ values of V1 neurons in Tg1 mice were significantly lower than those in WT mice at 8 weeks. The difference in C₅₀ between V1 neurons in WT and Tg1 mice was not statistically significant at 14 weeks. n = 187 neurons from 19 WT mice at 8 weeks, n = 258 neurons from 28 WT mice at 14 weeks, n = 259 neurons from 23 Tg1 mice at 8 weeks, n = 173 neurons from 19 Tg1 mice at 14 weeks. (b) Mean C₅₀ values for V1 neurons in each cortical layer for WT and Tg1 mice at 8 weeks. WT mice: n = 3, 21, and 116 for layer 2/3, 4, and 5/6, respectively. Tg1 mice: n = 6, 48, and 137 for layer 2/3, 4, and 5/6, respectively. Only those recordings whose laminar locations could be determined from the CSD analysis were used for laminar analysis. Error bars, ±s.e.m., **P < 0.01, ***P < 0.001, two-way ANOVA followed by Tukey’s multiple comparison test for (a), Wilcoxon rank sum test with Bonferroni’s correction for multiple comparisons for (b).