Table 1.
Distribution of secretor status (FUT2), Lewis genotype (FUT3) and ABO types among cases with rotavirus gastroenteritis of distinct severities and healthy control subjects.
| HBGAs genotype | Cases | Controls N = 133 (%) | P 1 * | P 2 * | ||
|---|---|---|---|---|---|---|
| All N = 68 (%) | Moderate N = 13 (%) | Severe N = 55 (%) | ||||
| FUT2 | 0.62 | <0.001 | ||||
| Secretor genotype$ | 67 (99) | 13 (100) | 54 (98) | 101 (76) | ||
| Se/Se | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| Se/C357T | 11(16) | 2 (15) | 9 (17) | 9 (6.7) | ||
| Se/A385T | 10 (15) | 2 (15) | 8 (15) | 15 (11) | ||
| Se/C571T | 0 (0) | 0 (0) | 1 (1.0) | 1 (0.8) | ||
| C357T/C357T | 15 (22) | 3 (23) | 12 (22) | 20 (15) | ||
| C357T/A385T | 29 (43) | 6 (46) | 23 (42) | 52 (39) | ||
| C357T/C571T | 1 (1.5) | 0 (0) | 1 (1.8) | 3 (2.3) | ||
| C357T/G849A | 1 (1.5) | 0 (0) | 1 (1.8) | 1 (0.8) | ||
| Weak-secretor genotype$ | 1 (1.5) | 0 (0) | 1 (1.8) | 32 (24) | ||
| A385T/A385T | 0 (0) | 0 (0) | 0 (0) | 29 (22) | ||
| A385T/C571T | 1 (1.5) | 0 (0) | 1 (1.8) | 1 (0.8) | ||
| A385T/G849A | 0 (0) | 0 (0) | 0 (0) | 2 (1.5) | ||
| FUT3 | 0.62 | 0.03 | ||||
| Lewis-positive genotype# | 67 (99) | 13 (100) | 54 (98) | 120 (90) | ||
| Le/Le | 42 (62) | 9 (69) | 33 (60) | 56 (42) | ||
| Le/G508A | 17 (25) | 3 (23) | 14 (26) | 25 (19) | ||
| Le/T1067A | 8 (12) | 1 (7.7) | 7 (13) | 39 (29) | ||
| Lewis-negative genotype# | 1 (1.5) | 0 (0) | 1 (1.8) | 13 (9.8) | ||
| G508A/T1067A | 1 (1.5) | 0 (0) | 1 (1.8) | 13 (9.8) | ||
| ABO blood type | 0.37 | 0.47 | ||||
| Type A | 28 (4) | 3 (23) | 25 (46) | 46 (35) | ||
| Type B | 12 (18) | 2 (15) | 10 (18) | 27 (20) | ||
| Type O | 23 (34) | 6 (46) | 17 (31) | 55 (41) | ||
| Type AB | 5 (7.4) | 2 (15) | 3 (5.5) | 5 (3.8) | ||
Abbreviations: HBGA, Histo-blood group antigen; Se, wild-type of the FUT2 gene; Le, wild-type of the FUT3 gene.
*P 1 statistical test between the case subjects with moderate diseases and those with severe diseases. *P 2 statistical test between the case subjects and the control subjects.
$The secretors carried at least one wild-type (Se) allele or the silent mutation (C357T) in the FUT2 gene. The weak secretors carried a missense mutation (A385T) in at least one allele of the FUT2 gene that led to an amino acid change of I129F. The single nucleotide polymorphisms of C571T and G849A are both nonsense mutations.
#Lewis-positive genotype indicates that at least one allele is wild-type (Le). Lewis-negative genotype indicates that both FUT3 alleles harbor nonsense mutations including G508A or T1067A.