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. 2017 Jul 26;9:243. doi: 10.3389/fnagi.2017.00243

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Copyright © 2017 Wang, Fang, Wang, Yang, Yu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Statistical analysis of filtered wavelet bicoherence value (FIWBIC) in the AD group compared with the HC group and topgraphic distribution of statistical differences. (A) Scatter plot for phase coupling at local frequency bands in the HC group (black) and AD group (red).The Y-axis represented the mean of synchronization. The synchronization values increased between between beta and delta/theta/alpha, and between gamma and delta/alpha/beta. *P_FDR < 0.05, **P_FDR < 0.01, (n = 8–12). (B) Topographic distribution of statistical significances in cross-frequency coupling between two groups. Values were color coded. Black: P < 0.001; dark gray: P < 0.01; light gray: P < 0.05; white: not significant, uncorrected for the number of electrodes tested.