Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 25;7:6471. doi: 10.1038/s41598-017-01705-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Rv2887-SA and Rv2887-PAS complex structures show that SA and PAS bind to Rv2887 in a similar manner (A) Representative binding isotherms of SA (left) PAS (centre) and gemfibrozil (right) titrated into Rv2887, as determined by isothermal titration calorimetry. (B) Secondary structure of apo Rv2887. Elements of one of the subunits, the dimerization interface and the winged helix-turn-helix motif (wHTH) are labelled. (C) Secondary structure superposition of the Rv2887-PAS dimer (blue) and the Rv2887-SA dimer (green). (D) Stereo image of the SA binding pocket; residues from Rv2887 are shown as sticks. Polar contacts are shown as green dashed lines, and the red sphere is a water molecule. (E) Stereo image of the PAS binding pocket; residues from Rv2887 are shown as sticks. Ligands SA and PAS are surrounded by ligand-omit 1Fo-Fc electron density maps (magenta) contoured and 3.0 σ. Polar contacts are shown as red dashed lines, and the yellow sphere is a water molecule. (F) Stereo image of the superposition of the PAS binding pocket and the SA binding pocket.