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. 2017 Jul 25;7:6352. doi: 10.1038/s41598-017-06583-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ion distribution images of three different endogenous compounds. (a–c) MALDI MSI ion distribution images of three different endogenous compounds (m/z 772 (green), m/z 769 (red) m/z 804 (blue)) representing different anatomical structures of the intestine lamina propria, submucosa, and epithelial cell layer, respectively. Data was acquired at three different spatial resolutions on three different tissue sections from intestine (a) 15 µm, (b) 10 µm, and (c) 5 µm. The ion intensities are displayed on monochrome colour scales where red is scaled to 50% of max intensity, blue is scaled to 25% of max intensity, and green is scaled to 60% of max intensity. Scale bar 100 µm. (d) H&E stained image of fresh frozen rat intestine processed in same way as sections for MSI analysis with annotated regions of the intestine. GI-L = gastrointestinal lumen; V = villi, oval circle villus tips; SM = submucosa; E = epithelial enterocytes (dark eosinophilic stain); G = goblet cell (arrow tip, not stained in H&E); LP = lamina propria; C = crypt base; S = serosa; LM = longitudinal muscle; CM = circular muscle.