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. 2017 Jul 25;7:6446. doi: 10.1038/s41598-017-06657-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Schematic illustration of a sensitive acupuncture needle microsensor for real-time monitoring of NO in acupoints of rats. (b) Schematic diagram of the FGPC/AuNPs/acupuncture needle. (c) Schematic diagram of real-time NO measurement in acupoint ST 36 stimulated by _L-arginine.