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. 2017 Jul 25;7:6440. doi: 10.1038/s41598-017-06809-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rmrp RNA and RNase MRP subunit expression responds to chondrogenic differentiation of ATDC5 cells. ATDC5 cells were differentiated in the chondrogenic lineage for 0, 7, 14, 21 or 28 days. (A) Different stages of chondrogenic differentiation were confirmed by measuring gene expression of Col2a1, Col10a1 and osteocalcin. (B) Expression of Rmrp RNA and RNase MRP protein subunits Rpp30 and Rpp40 is depicted as fold induction relative to t = 0. Data was normalized to β-actin and represents the average value of 3 biological replicates plus standard deviation. For statistical evaluation an independent samples t-test was performed between each consecutive time point using GraphPad Prism 5. p-values are indicated. Presented graphs are representative examples of three independent experiments.