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. 2017 Jul 25;7:6409. doi: 10.1038/s41598-017-06600-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The impact of DT-induced damage on AM response. The frequency of the carrier was 16 kHz. The AM CAP were measured with Fm of 112 Hz (A,C) and 996 Hz (B,D) respectively, and shown as the amplitude (A and B) and ratio change (C and D) as the function of modulation depths in percentage. The AM CAP was significantly smaller in Cre⁺ group, especially at larger modulation depth. *p < 0.05, **p < 0.01, and ***p < 0.001.