Table 3.
Association between genetic risk score from the 13 human height genetic loci and FSS risk
| Weighted genetic risk score (wGRS) quartile | FSS (%) | Controls (%) | OR | 95% CI | P value |
|---|---|---|---|---|---|
| N = 978 | N = 1129 | ||||
| N (%) | N (%) | ||||
| Q1 | 144 (14.7) | 412 (36.5) | Ref. | Ref. | Ref. |
| Q2 | 199 (20.3) | 282 (25.0) | 2.02 | 1.55–2.63 | <0.001 |
| Q3 | 254 (26.0) | 278 (24.6) | 2.61 | 2.03–3.37 | <0.001 |
| Q4 | 381 (39.0) | 157 (13.9) | 6.94 | 5.32–9.06 | <0.001 |
| Cochran-Armitage Trend Test | <0.001 |
Abbreviations: FSS, familial short stature; OR, odds ratio; CI, confidence interval; Ref., reference.
The 13 human height genetic loci and the respective risk genotypes were shown in Table S3.
The controls were the individuals whose body height was 75% above the general population in Taiwan.
Weighted genetic risk score quartile 1 (Q1): 0 < wGRS <= 11.88; Weighted genetic risk score quartile 2 (Q2): 11.88 < wGRS <= 13.50; Weighted genetic risk score quartile 3 (Q3): 13.50 < wGRS <= 15.05; Weighted genetic risk score quartile 4 (Q4): 15.05 < wGRS.