Table 1.
The effect of hyperoside pre-treatment on proteinuria, glucose and lipid metabolism, blood pressure, serum RAS and ROS in DN mice (n = 15).
| Index | Control | DN | LHPS | HHPS |
|---|---|---|---|---|
| UmAlb/Cr (mg/g) | 16.5 ± 3.8 | 115.4 ± 14.2a | 98.5 ± 10.5a | 68.6 ± 7.3a,b |
| FBG (mmol/L) | 5.7 ± 0.8 | 15.8 ± 2.8a | 15.7 ± 2.4a | 15.4 ± 3.3a |
| HbA1c (%) | 5.6 ± 0.8 | 10.5 ± 1.5a | 10.2 ± 1.4a | 10.3 ± 1.2a |
| MAP (mmHg) | 80.2 ± 5.8 | 82.6 ± 6.6 | 82.6 ± 5.4 | 82.3 ± 5.8 |
| TC (mmol/L) | 4.2 ± 0.5 | 4.9 ± 0.6 | 4.5 ± 0.7 | 4.6 ± 0.6 |
| LDL (mmol/L) | 2.3 ± 0.5 | 3.1 ± 0.6a | 2.9 ± 0.5a | 3.0 ± 0.5a |
| Ang II (pg/ml) | 52.8 ± 7.3 | 68.3 ± 11.2a | 66.4 ± 10.4a | 62.7 ± 9.8a |
| Aldosterone (pg/ml) | 108.4 ± 11.6 | 128.5 ± 10.4a | 125.2 ± 11.6a | 124.6 ± 13.5a |
| MDA (µmol/L) | 3.2 ± 0.4 | 9.7 ± 1.5a | 6.4 ± 0.8a,b | 5.2 ± 0.7a,b |
| SOD (mU/L) | 48.3 ± 6.5 | 22.3 ± 4.1a | 34.5 ± 6.2a,b | 40.6 ± 5.7a,b |
Control: Normal mice; DN: DM mice were treated with vehicle solution; LHPS and HHPS: DM mice were treated with 10 or 30 mg/kg/d hyperoside for four weeks from two weeks after DM establishment respectively. Data are presented as mean ± SD. P < 0.05 is statistically significant. aIndicates significant vs. Control, bindicates significant vs. DN.