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| Response model | Sum of squares | df | Means square | F value | P value | R 2 | Adequate precision |
| Swelling index at 3 hrs | 59769.36 | 5 | 11953.87 | 186.59 | 0.0006 | 0.9968 | 29.009 |
| Swelling index at 5 hrs | 80694.67 | 5 | 16138.93 | 328.62 | 0.0003 | 0.9982 | 37.691 |
