Table 1. The equilibrium Solubility of Griseofulvin in Various Oils, Surfactants and Cosurfactants (Mean ± SD, n = 3) .
Phase type | Excipient | Solubility (mg/ml) |
oil | Oleic acid | 2.66 ± 0.15 |
Oleic acid + transcutol P | 3.61 ± 0.04 | |
Isopropyl Myristat | 2.01 ± 0.07 | |
IsopropyMyristat + transcutol | 3.50 ± 0.20 | |
surfactant | Tween 80 | 3.06 ± 0.30 |
Span 20 | 3.09 ± 0.10 | |
Labrasol | 4.36 ± 0.15 | |
co-surfactant | Pleurol Oleic | 2.60 ± 0.10 |
Propylene glycol | 1.00 ± 0.01 |