Fig. 1. A p38-centric view of cellular homeostasis.

A stylized cell with dark grey endoplasmic reticulum, light grey mitochondria and a while nucleus is shown. A sampling of factors leading to increased presence of activated (phosphorylated, P-p38) p38 are shown with blue arrows/black writing, while events downstream of p38 activation (green) are shown with red arrows and writing. ASK-1 (Apoptosis signaling kinase 1), TRAF2 (TNF receptor-associated factor 2), GADD45α (Growth arrest and DNA-damage-inducible protein GADD45 alpha), TNF (Tumor necrosis factor), IL-1 (Interleukin 1), NF-κb (nuclear factor kappa B) are all shown as representative molecules in the p38 ‘universe’.