Table 1. Association between rs6489956 in the 3′UTR region of TBX5 and risk of congenital heart disease in two independent case–control studies.
| Group | Genotype/Allele | Control | Case |
Logistic regression |
HWEpa | |
|---|---|---|---|---|---|---|
| OR (95% CI) | P-valueb | |||||
| Shandong | C/C | 534(88.1%) | 703(77.7%) | 1.00 | 1.65×10−7 | 0.085 |
| C/T-T/T | 72(11.9%) | 202(22.3%) | 2.33 (1.70–3.19) | |||
| C | 1 135(93.6%) | 1 595(88.1%) | 1.00 | 2.86×10−7 | ||
| T | 77(6.4%) | 215(11.9%) | 2.16 (1.61–2.91) | |||
| Shanghai | C/C | 318(82.8%) | 197(72.4%) | 1.00 | 0.0013 | 0.54 |
| C/T-T/T | 66(17.2%) | 75(27.6%) | 1.75 (1.24–2.46) | |||
| C | 698(90.9%) | 462(84.9%) | 1.00 | 0.001 | ||
| T | 70(9.1%) | 82(15.1%) | 1.77 (1.26–2.49) | |||
| Combined | C/C | 852(86.1%) | 900(76.5%) | 1.00 | 3.62×10−8 | 0.1 |
| C/T-T/T | 138(13.9%) | 277(23.5%) | 1.83 (1.48–2.28) | |||
| C | 1 833(92.6%) | 2 057(87.4%) | 1.00 | 2.01×10−8 | ||
| T | 147(7.8%) | 297(12.6%) | 1.86 (1.50–2.30) | |||
Abbreviations: CI, confidence interval; HWE, Hardy-Weinberg equilibrium; OR, odds ratio.
a
P-value for HWE test in control subjects.
b
Adjusted for age and gender. The bold entries indicate significant P values.