Table 2. Stratified analysis of rs6489956 by CHDs classification.
| No. | P-value | Association (OR (95% CI))a CT/TT vs CC | |
|---|---|---|---|
|
CHDs classification Ib | |||
| Conotruncal defects | 156 | 4.63×10−5 | 2.35 (1.56–3.54) |
| Septal defects | 830 | 1.71×10−6 | 1.85 (1.44–2.39) |
| LVOTO | 17 | 0.171 | 2.27 (0.70–7.29) |
| RVOTO | 24 | 0.114 | 2.14 (0.83–5.52) |
| APVR | 16 | 0.94 | 0.94 (0.21–4.25) |
| Complex CHDs | 14 | 0.025 | 3.58 (1.17–10.93) |
| Other cardiac abnormalities | 120 | 0.006 | 2.22 (1.26–3.93) |
|
CHDs classification II | |||
| Isolated CHDs | 1 016 | 6.67×10−7 | 1.85 (1.45–2.36) |
| Non-isolated CHDs | 161 | 9.83×10−7 | 2.68 (1.81–3.98) |
|
Detailed CHDs phenotypes | |||
| ASD | 120 | 3.67×10−3 | 2.00 (1.25–3.18) |
| VSD | 691 | 2.69×10−5 | 1.76 (1.35–2.30) |
| TOF | 98 | 0.031 | 1.78 (1.06–3.02) |
Abbreviations: APVR: anomalous pulmonary venous return; ASD: atrial septal defect; LVOTO: left ventricular outflow tract obstruction; RVOTO: right ventricular outflow tract obstruction; TOF: tetralogy of Fallot; VSD: ventricular septal defect.
a
Adjusted for age and gender.
b
Classification described in Botto et al. [24].The bold entries indicate significant P values.