FIG 1 .

LpxC inhibitors LPC-058 and LPC-069 display antibiotic activity against Y. pestis in vitro. The molecular structures of LPC-058 and LPC-069, including common features and structural differences, are depicted. The MICs of LPC-058 and LPC-069 were determined for two strains of each of three Y. pestis biovars, grown at the optimal growth temperature (28°C) or at the host temperature (37°C) in Mueller-Hinton medium (MH) supplemented or not with serum albumin (SA). The MICs of LPC-058 and LPC-069 determined with E. coli grown at 37°C in MH medium are also reported. The MICs were determined from three independent biological replicates.