FIG 7 .

A hypothetical model of the regulation of Gal-3 and Gal-8 in GAS replication in epithelial cells and endothelial cells. Higher levels of expression and recruitment of Gal-3 in endothelial cells inhibit the recruitment of Gal-8 and parkin to GAS, resulting in less ubiquitin recruitment and more GAS replication. In contrast, higher levels of expression and recruitment of Gal-8 in epithelial cells inhibit the recruitment of Gal-3 but induce the recruitment of parkin, resulting in higher ubiquitin recruitment and GAS elimination.