Figure 1.

Pedigrees and germline variants detected in families with a history of SI-NETs. Clinically affected subjects are indicated by filled symbols. Females are designated by circles and males by squares, while individuals with unknown gender are depicted as diamonds. All affected and controls subjects studied for mutations are marked by arrows. Different variants that were considered as candidates for mutations contributing to disease development are depicted in different colors and explained in the legend under each pedigree. All these variants were present as a single allele in the germline of the tested individuals.