Figure 3.

Venn diagram showing the different tissues analyzed for the sporadic SI-NETs. DNA extracted from a total of 296 sample tissues from 215 unrelated subjects was screened for the seven candidate variants. Samples were available from tumors (PT and/or metastases) and cancer-free tissues (blood and/or NT from liver). Clinical details, type and number of samples tested for each affected individual are described in Supplementary Table 1. Samples for multiple tissues (two to four) were available for 68 sporadic patients while 147 of these had only one specimen represented in our collection. All subjects with a NT available for our analyses (n = 30) were also sampled for another tissue, either blood or tumor/metastasis.