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. 2017 Mar 29;11(5):455–469. doi: 10.1002/1878-0261.12036

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© 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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ZFX is frequently upregulated in HCC tissues and predicts poor prognosis in patients with HCC. (A) The expression levels of ZFX mRNA in 50 paired HCC and their adjacent nontumorous tissues were evaluated by qRT‐PCR. (B) The expression of ZFX protein in tumor samples (T) and their corresponding peri‐tumoral tissues (N) from 18 patients with HCC were analyzed by western blots. (C) Representative IHC staining of ZFX expression in peri‐tumoral tissue and HCC samples is shown (scale bar = 50 μm). (D,E) Kaplan–Meier analysis of the association between ZFX expression levels and disease‐free survival (DFS) or overall survival (OS) in patients with HCCs (n = 242).