Table 2.

Impact of prognostic factors on TFS and OS by univariate analysis in osteosarcoma

Clinicopathologic parameters	Tumor‐free survival				Overall survival
	NO.	HR	95% CI	P	NO.	HR	95% CI	P
Gender
Male	81	0.780	0.489–1.244	0.297	81	0.586	0.333–1.032	0.064
Female	70				70
Age (years)
6–20	82	1.227	0.948–1.586	0.120	82	1.239	0.911–1.685	0.172
20–40	46				46
40–60	16				16
60–84	7				7
Location
Femur	81	0.983	0.724–1.334	0.912	81	0.859	0.585–1.262	0.439
Tibia	44				44
Elsewhere	26				26
Tumor necrosis rate (%)
≥ 90	121	0.595	0.313–1.133	0.114	121	0.636	0.299–1.352	0.239
≥ 90	30				30
Cortical destruction
Yes	127	1.215	0.622–2.371	0.569	127	1.301	0.586–2.887	0.518
No	24				24
CNOT1
Negative	31	1.454	1.161–1.821	0.001a	31	1.676	1.277–2.199	0.000a
Low	46				46
Middle	37				37
Strong	37				37
Enneking stage
II	113	2.268	1.402–3.668	0.001a	113	2.985	1.726–5.161	0.000a
III	38				38

P < 0.05.