Table 1.
GSEA. GSEA identified several functional genesets significantly enriched in xenografts treated with estradiol versus non‐treated. Analysis was conducted in MAS98.06 and MAS98.12 separately and genesets with FDR less than 0.25 were considered as ‘significant’ and reported in the table.
| Name | NES | FDR q‐val | |
|---|---|---|---|
| Enriched in treated MAS98.06 xenografts | SIG_BCR_SIGNALING_PATHWAY | 2.236 | 0.042 |
| CELLCYCLEPATHWAY | 2.141 | 0.051 | |
| FRASOR_ER_UP | 2.111 | 0.044 | |
| IL2RBPATHWAY | 2.013 | 0.094 | |
| ST_B_CELL_ANTIGEN_RECEPTOR | 1.915 | 0.149 | |
| GLUT_DOWN | 1.856 | 0.191 | |
| INFLAMMATORY_RESPONSE_PATHWAY | 1.817 | 0.213 | |
| SIG_IL4RECEPTOR_IN_B_LYMPHOCYTES | 1.782 | 0.223 | |
| TESTIS_GENES_FROM_XHX_AND_NETAFFX | 1.765 | 0.216 | |
| SA_B_CELL_RECEPTOR_COMPLEXES | 1.762 | 0.195 | |
| Enriched in non‐treated MAS98.06 xenografts | CELL_CYCLE_ARREST | –1.909 | 0.114 |
| NOS1PATHWAY | –1.815 | 0.123 | |
| MAP00190_OXIDATIVE_PHOSPHORYLATION | –1.717 | 0.164 | |
| CELL_CYCLE_CHECK POINT | –1.589 | 0.250 | |
| Enriched in treated MAS98.12 xenografts | – | – | – |
| Enriched in non‐treated MAS98.12 xenografts | ST_B_CELL_ANTIGEN_RECEPTOR | –2.641 | 0.000 |
| EMT_UP | –2.055 | 0.096 | |
| ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | –1.878 | 0.268 | |
| PDGFPATHWAY | –1.868 | 0.201 | |
| ERKPATHWAY | –1.859 | 0.164 | |
| TCRPATHWAY | –1.816 | 0.194 | |
| SIG_IL4RECEPTOR_IN_B_LYMPHOCYTES | –1.790 | 0.195 | |
| ST_G_ALPHA_I_PATHWAY_ | –1.734 | 0.230 | |
| GHPATHWAY | –1.724 | 0.222 | |