TABLE 1.
Patient characteristicsa
| Variable | Valueb |
|---|---|
| Continuous | |
| Demography | |
| Age (yr) | 34.0 (28.0–40.0) |
| Body wt (kg) | 50.5 (46.0–56.0) |
| BMI (kg/m2) | 19.2 (17.5–21.0) |
| Baseline hematology | |
| Hemoglobin (g/dl) | 12.3 (10.9–13.6) |
| Leukocyte (109cells/liter) | 4.7 (3.7–5.9) |
| Neutrophils (109cells/liter) | 46.0 (4.0–61.0) |
| Thrombocytes (109cells/liter) | 241.0 (182.0–312.5) |
| Albumin (g/liter) | 3.9 (3.4–4.3) |
| Baseline liver function panel | |
| AST (U/liter) | 34.0 (27.5–49.0) |
| ALT (U/liter) | 28.0 (24.0–26.0) |
| ALP (U/liter) | 111.0 (91.0–138.5) |
| Total bilirubin (μmol/liter) | 0.45 (0.3–0.9) |
| Direct bilirubin (μmol/liter) | 0.1 (0.1–0.13) |
| Baseline renal function panel | |
| Blood urea (mg/dl) | 24.0 (19.0–30.0) |
| Serum creatinine (μmol/liter) | 0.9 (0.7–1.0) |
| Baseline virology and immunology | |
| HIV RNA (log10 copies/ml) | 5.2 (4.5–5.5) |
| CD4 cells/mm3 | 101.0 (54.5–149.5) |
| Categorical | |
| Rifampin-based anti-TB regimen | |
| Yes | 81 |
| No | 232 |
| Sex | |
| Males | 104 |
| Females | 209 |
| HBsAg | |
| Yes | 17 |
| No | 296 |
| HCV | |
| Yes | 6 |
| No | 307 |
| CYP2B6*6 (516G→T) | |
| GG | 144 |
| GT | 134 |
| TT | 20 |
| ABCB1 (3435C→T) | |
| CC | 185 |
| CT | 99 |
| TT | 14 |
| ABCB1 (3842A→T) | |
| AA | 222 |
| AG | 73 |
| GG | 7 |
| CYP3A5*3 (6986A→G) | |
| AA | 37 |
| AG | 140 |
| GG | 121 |
| CYP3A5*6 (14690G→A) | |
| GG | 222 |
| GA | 69 |
| AA | 7 |
| UCT2B7*2 (372G→A) | |
| GG | 74 |
| GA | 163 |
| AA | 65 |
| OATP1B1*1B (388A→G) | |
| AA | 45 |
| AG | 152 |
| GG | 105 |
| OATP1B1*5 (521T→C) | |
| TT | 202 |
| TC | 82 |
| CC | 18 |
a
BMI, body mass index; HIV RNA, RNA of human immunodeficiency virus; CD4, cluster of differentiation 4; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; IQR, interquartile range; AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase.
b
Values for continuous variables are medians (IQRs); values for categorical variables are n.