TABLE 1.
Overview of mobile genetic elements, pathogenicity islands, and amino acid exchanges conferring antibiotic resistance for 3 ST247 strains
| Feature | Datum for strain: |
||
|---|---|---|---|
| SA1450/94 | SA137/93A | SA137/93G | |
| Total no. of IS elements | 46 | 63 | 53 |
| No. of copies of IS elements | |||
| IS256 | 33 | 44 (chromosome) + 1 (pSA93A) | 39 |
| IS1181 | 5 | 7 | 7 |
| IS431mec | 1 | 2 (chromosome) + 2 (pSA93A) | 1 |
| IS1272 | 1 | 1 | |
| IS1272 related | 6 | 6 | 6 |
| Free plasmid pSA93A | pSA93A: merA, merB, cadA, blaZ, qacA | ||
| Integrated pUB110 | pUB110: aadD, bleO | ||
| Transposons | Tn4001: aac(6′)-aph(2″) Tn5801 variant: tetM Tn554: ermA, ant9-Ia | Tn4001: aac(6′)-aph(2″) Tn5801 variant: tetM Tn554: ermA, ant9-Ia | Tn4001: aac(6′)-aph(2″) Tn5801 variant: tetM Tn554: ermA, ant9-Ia |
| SCCmec cassette | Type I | Type IA | Deleted (18) |
| No. of prophages (complete) | 4 | 3 | 3 |
| No. of prophages (incomplete) | 2 | 2 | 2 |
| No. of pathogenicity islands (νSaα, νSaβ, νSaγ) | 3 | 3 | 3 |
| Exchanges in RpoBa | H481N, L875S, V798A | H481N, L875S, V798A, S529L | H481N, L875S, V798A, S529L |
| Exchange in GyrAb | S84L | S84L | S84L |
| Exchange in ParCb | S80F | S80F | S80F |
a
Exchanges in RpoB confer resistance to rifampin (H481N, L875S, and V798A) and the S529L exchange was previously observed in a VISA strain (58).
b
Exchanges in in GyrA and ParC confer resistance to quinolones.