TABLE 2.
Urine recovery of CMS and formed colistin
| Patient | CMS daily dose (MIU/h) | Concn of formed colistin in urine (mg/liter) |
Range of concn of CMS in urine (mg/liter)a | CMS urinary recovery (%)a |
% of CMS urinary recovery recovered as colistina |
Urine vol collected in 6 h/24 h (ml)b | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0–2 h | 2–4 h | 4–6 h | 0–2 h | 2–4 h | 4–6 h | 0–6 h | 0–2 h | 2–4 h | 4–6 h | 0–6 h | ||||
| 1 | 1/24 | 0.5 | 1 | 1.7 | 3.2–18.9 | 0.9 | 1.9 | 0.0 | 2.9c | 6.7 | 14.4 | 0.0 | 18.1 | 105/750 |
| 2 | 1/8 | 0.6 | 0.2 | 0.1 | 1.5–64.8 | 21.0 | 3.6 | 0.6 | 25.3 | 1.2 | 3.7 | 6.7 | 11.6 | 790/3,050 |
| 3 | 1/8 | 5.2 | 12.5 | 4.6 | 37.3–139.2 | 21.4 | 20.9 | 5.3 | 47.6 | 6.8 | 11.2 | 8.2 | 26.2 | 300/1,400 |
| 4 | 2/12 | 3.0 | 4.8 | 1.8 | 11.1–67.3 | 7.3 | 5.4 | 3.8 | 16.6 | 7.9 | 9.0 | 11.0 | 27.9 | 560/3,690 |
| 5 | 2/8 | 25.9 | 19.0 | 9.3 | 105.4–362 | 24.8 | 7.8 | 10.0 | 42.6 | 9.8 | 6.9 | 8.6 | 25.3 | 230/2,650 |
| 6 | 2/8 | 8.3 | 14.7 | 15.8 | 58–211.3 | 1.2 | 1.5 | 18.1 | 20.9 | 6.3 | 8.9 | 12.2 | 27.5 | 170/1,200 |
| 7 | 3/8 | 23.9 | 1.9 | 5.1 | 78.3–491.4 | 46.7 | 1.4 | 1.3 | 49.4 | 6.4 | 2.6 | 5.0 | 13.9 | 250/NQ |
| 8 | 3/8 | 21.3 | 18.8 | 8.5 | 58.7–194.1 | 29.9 | 10.9 | 8.3 | 49.0 | 13.4 | 14.1 | 16.1 | 43.5 | 680/2,450 |
| 9 | 4.5/12 | 6.1 | 43.9 | 95.4 | 9.2–1699.6 | 0.2 | 36.6 | 40.8 | 72.8 | 14.8 | 5.0 | 7.3 | 27.1 | 185/1,600 |
| 10 | 2/8 | 14.6 | 7.3 | 12.2 | 187.–294.4 | 4.2 | 20.0 | 13.7 | 37.8 | 6.5 | 3.4 | 8.4 | 18.3 | 220/NQ |
| 11 | 2/12 | 13.9 | 10.6 | 8.9 | 114.4–256.4 | 7.4 | 48.4 | 14.3 | 65.4 | 7.1 | 6.1 | 8.2 | 21.4 | 480/1,600 |
| 12 | 2/8 | 28.8 | 8.5 | 1.0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 1,026/4,150 |
a
NA, not available.
b
NQ, not quantified.
c
Collected in 4 h.