FIG 1.

In vivo dose-response curves for 9 C. auris strains against fluconazole (A), micafungin (B), and amphotericin B (C). Each symbol represents the mean and standard deviation (error bars) of burden in the kidneys of three mice. The horizontal dashed line represents the burden at the start of therapy. The relationship between PK/PD index (AUC/MIC or C_max/MIC) and efficacy for fluconazole (D), micafungin (E), and amphotericin B (F) are also shown. Each symbol represents the mean burden from three mice, and the horizontal dashed line is the burden at the start of therapy. A best-fit line based on the Hill equation is shown, as are the PD parameters maximum effect (E_max), ED₅₀, slope (N), and the coefficient of determination (R²).