TABLE 2.

Clinical characteristics and dosage for participants enrolled^a

Group	Age (yrs)	Sex (M/F)	Wt (kg)	Creatinine level (μmol/liter)	HCT level	Clinical indication	Penicillin dose and formulation
1	19	M	62	89	0.47	Primary syphilis	Benzathine penicillin G 1.8 g
1	40	M	70	67	0.42	Primary syphilis	Benzathine penicillin G 1.8 g
1	40	M	89	71	0.51	Secondary syphilis	Benzathine penicillin G 1.8 g
1	46	M	198	70	0.46	Recurrent lower leg cellulitis	Benzathine penicillin G 1.8 g
2	35	M	81	68	0.37	Infective endocarditis	Benzylpenicillin 1.8 g 4 hourly
2	58	M	81	116	0.33	Infective endocarditis	Benzylpenicillin 1.8 g 4 hourly
2	87	F	95	74	0.23	Prosthetic joint infection	Benzylpenicillin 1.8 g 4 hourly
2	36	M	92	66	0.25	Endovascular infection	Benzylpenicillin 1.8 g 4 hourly
3	64	M	54	50	0.36	Osteoarticular infection	Benzylpenicillin infusion 10.8 g over 24 h
3	88	F	69	79	0.31	Intra-abdominal actinomycosis	Benzylpenicillin infusion 7.2 g over 24 h
3	83	F	63	52	0.35	Osteoarticular infection of the spine	Benzylpenicillin infusion 10.8 g over 24 h
3	71	M	90	75	0.41	Bacteremia	Benzylpenicillin infusion 10.8 g over 24 h
3	28	F	53	57	0.33	Bacteremia	Benzylpenicillin infusion 10.8 g over 24 h
3	73	F	110	359	0.33	Bacteremia	Benzylpenicillin infusion 5.4 g over 24 h
3	51	M	89	102	0.36	Infective endocarditis	Benzylpenicillin infusion 14.4 g over 24 h
3	53	M	130	94	0.42	Osteoarticular infection	Benzylpenicillin infusion 10.8 g over 24 h
3	70	M		115	0.43	Infective endocarditis	Benzylpenicillin infusion 10.8 g over 24 h

^aF, female; M, male; HCT, hematocrit.