TABLE 1.
Baseline parameters
| Parametera | Azole monotherapy (N = 25)b | Echinocandin or polyene (N = 43)b | P |
|---|---|---|---|
| Gender (F) | 11 (44) | 22 (51) | 0.6 |
| Age (yrs) | 57 ± 14 | 54 ± 15 | 0.4 |
| Acute leukemia | 3 (12) | 7 (16) | 0.6 |
| HSCT | 4 (16) | 2 (5) | 0.1 |
| ANC < 500/μl | 4 (16) | 10 (23) | 0.5 |
| ALC < 100/μl | 4 (16) | 13 (30) | 0.2 |
| AMC < 100/μl | 7 (28) | 14 (33) | 0.7 |
| ICU | 7 (28) | 23 (54) | 0.04 |
| APACHE II score | 14 ± 7 | 15 ± 6 | 0.4 |
| Fever (temp > 100.4°F) | 12 (48) | 21 (49) | 0.9 |
| Mixed bloodstream infection | 3 (12) | 8 (19) | 0.5 |
| Central line-related candidemiac | 12 (48) | 23 (54) | 0.7 |
| Earlyd central line removal | 6 (24) | 10 (23) | 0.7 |
| Diabetes | 4 (16) | 6 (14) | 0.8 |
| CKD | 6 (24) | 7 (16) | 0.4 |
| AKI | 6 (24) | 21 (49) | 0.04 |
| 28-Day all-cause mortality | 13 (52) | 13 (30) | 0.07 |
a
Abbreviations: HSCT, hematopoietic stem cell transplantation; ANC, absolute neutrophil count; ALC, absolute lymphocyte count; AMC, absolute monocyte count; ICU, intensive care unit; APACHE, Acute Physiology and Chronic Health Evaluation; CKD, chronic kidney disease; AKI, acute kidney injury.
b
Values are number (percentage) or mean ± SD.
c
Colony count in a blood culture obtained via a central venous catheter (CVC) at least 5-fold greater than the colony count in a peripheral blood culture or a positive catheter tip culture.
d
Within 48 h after collection of blood for culture.