TABLE 2.
Factors associated with 28-day (from the day of candidemia, i.e., of positive blood culture collection) all-cause mortality in cancer patients with fluconazole-susceptible dose-dependent C. glabrata fungemiaa
| Parameters | Univariate Analysis |
Multivariate Analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| AMC < 100/μl | 2.65 | 1.22–5.74 | 0.014 | 3.94 | 1.69–9.19 | 0.001 |
| ICU | 1.97 | 0.9–4.29 | 0.088 | 2.95 | 1.15–7.6 | 0.025 |
| APACHE II score (per unit) | 1.06 | 1–1.13 | 0.04 | 1.06 | 0.99–1.13 | 0.08 |
| Fever (temp > 100.4°F) | 0.48 | 0.21–1.08 | 0.074 | |||
| Mixed bloodstream infection | 2.7 | 1.13–6.47 | 0.03 | |||
| Azole monotherapy | 2.08 | 0.98–2.12 | 0.06 | 3.77 | 1.59–8.9 | 0.003 |
a
Abbreviations: HR, hazard ratio; CI, confidence interval; AMC, absolute monocyte count; ICU, intensive care unit; APACHE, Acute Physiology And Chronic Health Evaluation; T, temperature.