FIG 1.

SAR114 MAb broad reactivity against the three main ClfA genotypes in vitro. Inhibition of fibrinogen binding to the three main ClfA genotypes was measured in the presence of serially diluted (from 666 μM to 2.55 μM) anti-ClfA MAb 11H10 (A) or SAR114 (B). Data are representative of three independent experiments. (C) Agglutination of S. aureus clinical isolates in the presence of human plasma. The graph shows the minimum concentration of 11H10 (■) and SAR114 (■) required to inhibit bacterial agglutination. Data are representative of two independent experiments. c-IgG, used as a negative control, did not show any inhibition at 200 μg/ml.